CBD how it works

How does CBD work? A detailed Guide

Probably you have read a plentitude of write-ups on the Internet that CBD for health truly works. You may be wondering if that is truly right, how it happens to attain such. Well, lots of myths and misconceptions surround the same topic, which prompts us to debunk all these details.

CBD works by interacting with the ECS 

The ECS, short for the Endocannabinoid System, is a unique organ for interacting with cannabinoids. As its name suggests, it produces its cannabinoids, scientifically called endocannabinoids. CBD, as a cannabinoid, maneuvers its way into the ECS to offer its high number of benefits.

It is nonetheless worth mentioning that not only do humans have the Endocannabinoid System, but also every other mammal. That typically explains why the usage of CBD on pets is on the rise to this particular day.
Now, we are going to break this further. It should be getting interesting even further.

How CBD interacts with the ECS

The Endocannabinoid System has neurotransmitters, which scientists call the cannabinoid receptors. This means they receive cannabinoids into the body by creating a strong bond, thus striking a deal with how they work.

These cannabinoids comprise CB1 and CB2.

Most of the CB1 receptors are present in the brain region. Under normal circumstances, these bind with Tetrahydrocannabinol (THC), the cannabis chemical compound that makes its users high.

CB2 receptors, on the other hand, are majorly present in the immune and the Central Nervous System. When one takes CBD, it binds with the CB2 receptors, thus giving the user the merits associated with the consumption of CBD products.

The CBD diffuses along with the bloodstream to reach the sufferer’s concern. For instance, let’s take an example where you take a CBD pill for alleviating either Dravet Syndrome or the Lennox-Gastaut Syndrome.

When you take that CBD capsule (Epidiolex), it gets absorbed into the body, thus leading to the CBD to diffuse along with the bloodstream to solve those epileptic conditions.

how cbd works

There is an exception, though

You shouldn’t be confused as at this point. Not all the times that CBD interacts with the ECS. One such scenario is when the consumer takes CBD for solving a skin condition. Applying CBD topically on the skin like a CBD ointment, CBD cream, or as lotion doesn’t necessitate the bond between CBD and the ECS.
Applying CBD on the skin works by inducing both the antioxidant and anti-inflammatory benefits of CBD. The CBD doesn’t make its way to the bloodstream, which explains why topicals can only get used for alleviating physical conditions affecting the skin.

Research about how CBD functions

It is worth mentioning that most of the pieces of research about how CBD works were conducted on animal models like rats.

And as we mentioned above, all mammals have the Endocannabinoid System. Those specimens, being mammals just like humans, can give somewhat the same results as it could be the case with humans.

One of the hugest organizations for researching whether CBD works or not is PubMed.

They have backed up that Cannabidiol (CBD) works by interacting with the Endocannabinoid System to help in solving addiction problems and assisting in managing pain.

For the case of using CBD for skin, they concluded that using CBD without the presence of THC helps in solving skin parameters, especially for sufferers with inflammatory backgrounds.

Summing up how CBD works

Well, you are now in the know-how that CBD functions in two different ways according to how the user introduces them into the body. That is, applying CBD topically helps in solving skin conditions physically, while using it in any other way that takes it into the body enables it to work by interacting with the CB2 receptors of the ECS.


Always seek out a professional for medical advice and always do your own research!



  1. Endocannabinoid System: https://en.wikipedia.org/wiki/Endocannabinoid_system
  2. How does CBD work? https://daddyburt.com/learn/taking-cbd/how-does-cbd-work/
  3. CBD and Cannabis Research: https://www.concussionalliance.org/cbd-research
  4. CBD for substance abuse: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390812/

CBD for skin: https://www.ncbi.nlm.nih.gov/pubmed/30993303